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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: XRCC1 All Species: 13.33
Human Site: S421 Identified Species: 29.33
UniProt: P18887 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P18887 NP_006288 633 69526 S421 E A S H S G G S G D E A P K L
Chimpanzee Pan troglodytes XP_512717 596 65689 S384 E A S H S G G S G D E A P K L
Rhesus Macaque Macaca mulatta XP_001100256 645 69984 T451 A K Y R P D W T Q D S T H L I
Dog Lupus familis XP_533653 654 71801 S442 G G S H S G S S G D E A P K L
Cat Felis silvestris
Mouse Mus musculus Q60596 631 68952 S420 E G D S H S E S G E D E A P K
Rat Rattus norvegicus Q9ESZ0 631 68817 S420 E G D S H S E S G E D E A P K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516926 549 59237 P361 G S S E E E A P R A P R K R P
Chicken Gallus gallus
Frog Xenopus laevis NP_001080711 651 73244 P422 D D S D E D E P P K A P L H K
Zebra Danio Brachydanio rerio NP_001003988 615 68071 S411 L M D G A E S S S E S E A E Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_572217 614 68751 A402 H S S P T A V A V T P A K K Q
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001180271 512 56847 M323 E S E E E E E M E E E E V V T
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 93.8 82.3 86 N.A. 86 86.5 N.A. 47.7 N.A. 53.9 51.1 N.A. 20.7 N.A. N.A. 38.8
Protein Similarity: 100 94.1 83 88.3 N.A. 91.1 91 N.A. 56.5 N.A. 67.7 68.8 N.A. 36.9 N.A. N.A. 55.1
P-Site Identity: 100 100 6.6 80 N.A. 20 20 N.A. 6.6 N.A. 6.6 6.6 N.A. 20 N.A. N.A. 13.3
P-Site Similarity: 100 100 20 80 N.A. 33.3 33.3 N.A. 20 N.A. 13.3 26.6 N.A. 40 N.A. N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 19 0 0 10 10 10 10 0 10 10 37 28 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 10 10 28 10 0 19 0 0 0 37 19 0 0 0 0 % D
% Glu: 46 0 10 19 28 28 37 0 10 37 37 37 0 10 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 19 28 0 10 0 28 19 0 46 0 0 0 0 0 0 % G
% His: 10 0 0 28 19 0 0 0 0 0 0 0 10 10 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10 % I
% Lys: 0 10 0 0 0 0 0 0 0 10 0 0 19 37 28 % K
% Leu: 10 0 0 0 0 0 0 0 0 0 0 0 10 10 28 % L
% Met: 0 10 0 0 0 0 0 10 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 10 10 0 0 19 10 0 19 10 28 19 10 % P
% Gln: 0 0 0 0 0 0 0 0 10 0 0 0 0 0 19 % Q
% Arg: 0 0 0 10 0 0 0 0 10 0 0 10 0 10 0 % R
% Ser: 0 28 55 19 28 19 19 55 10 0 19 0 0 0 0 % S
% Thr: 0 0 0 0 10 0 0 10 0 10 0 10 0 0 10 % T
% Val: 0 0 0 0 0 0 10 0 10 0 0 0 10 10 0 % V
% Trp: 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _